Congenital antiphospholipid syndrome revealed by neonatal catastrophic occlusion syndrome contemporary to hypernatremic dehydration

Abstract

We report the case of an 8 day-old newborn who presented with hypernatremic dehydration, distal digital gangrene, seizures, extensive bilateral nephromegaly and hematuria. Radiological exams proved the existence of bilateral renal venous thromboses and extensive bilateral cerebral infarctions. Investigations revealed positive anticardiolipin IgG titers of the baby and his mother. Hypernatremic dehydration was the major additive risk factor recognized in this infant. Other risk factors of neonatal thromboses were ruled out. This unusual catastrophic presentation is exceptional and often lethal.